PAGE 1 — THE PRACTAGE LONGEVITY FRAMEWORK (FULL INTEGRATION)

1. Why PractAge Solutions Exists

The world has entered the Precision Longevity Era—where biological age, metabolic resilience, inflammation, cognitive performance, and genetic risk can be measured, reversed, and optimized. PractAge Solutions integrates global best practices, advanced diagnostics, and real-time health intelligence into one model:

Test deeply. Diagnose precisely. Intervene early. Optimize continuously.

This is longevity as a system, not guesswork.

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2. Comprehensive Testing & Investigations for Longevity

A. Annual Foundational Panels

• CBC – anemia, infection, energy capacity
• CMP – kidney, liver, electrolytes, metabolism
• Lipid Panel – LDL, HDL, TG, plus LDL-P, ApoB, Lp(a) for true risk
• Glucose Metabolism Panel – glucose, HbA1c, fasting insulin, OGTT
• Metabolic markers – uric acid, adiponectin, GGT

B. Advanced Biological Aging Panels

• Inflammation: hs-CRP, IL-6, homocysteine, fibrinogen
• Hormones: thyroid, vitamin D, testosterone, DHEA-S, IGF-1, cortisol curve
• Oxidative Stress: 8-OHdG, glutathione, CoQ10
• Mitochondrial performance biomarkers
• Nutrient Panels: B-vitamins, magnesium, amino acids, fatty acids

C. Cancer Detection & Prevention

• Tumor markers (PSA, CA-19-9, CA-125, CEA, AFP)
• Liquid Biopsy Multi-Cancer Tests (ctDNA detection)
• Gender-specific screening
• Colonoscopy (45+) or FIT/Cologuard
• Full-body MRI

D. Advanced Cardiovascular Mapping

• CAC Score
• CIMT
• NMR Lipoprotein testing
• ApoB, NT-proBNP, Troponin, MPO

E. Imaging & Organ Health

• DEXA
• Abdominal ultrasound
• CT Angiography
• Brain MRI

F. GI & Microbiome Evaluation

• Colonoscopy or stool DNA
• Comprehensive Stool Analysis
• EGD (if indicated)

G. Genetic & Epigenetic Panels

• ApoE, MTHFR
• Polygenic scoring
• Telomere length
• Epigenetic clocks (GrimAge, PhenoAge, Horvath)

H. Functional Longevity Testing

• VO2 Max
• Grip strength, gait speed
• Cognitive Testing
• Sleep Study

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PAGE 2 — PRACTAGE CLINICAL OPTIMIZATION PROTOCOLS

1. Cardiovascular Disease Minimization

• Lifestyle: fiber, omega-3s, weight loss
• Medications: statins, ezetimibe, PCSK9 inhibitors
• Target LDL: <70 (primary), <55 (high risk)

Blood Pressure Optimization

• Target <120/80
• DASH diet, potassium foods, stress control

Endothelial Function & Inflammation

• Nitrates (greens), exercise
• Citrulline/arginine
• Dental health

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2. Optimal Glucose & Metabolic Control

• Target: HbA1c <5.4, fasting glucose 70–85, insulin <5
• CGM for precision tracking
• Time-restricted eating
• Walking after meals
• Supplements: berberine, magnesium
• Medications: metformin, GLP-1s, SGLT2 inhibitors

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3. Cognitive Optimization & Brain Longevity

• Testing: MoCA, MRI, micronutrients
• Performance enhancement: CoQ10, B vitamins, creatine, Omega-3
• Nootropics: Bacopa, Lion’s Mane
• Lifestyle: sleep, meditation, cold exposure

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4. Mitochondrial & Energy Optimization

• NAD+ precursors, CoQ10
• Magnesium, L-carnitine
• Thyroid optimization
• Iron balancing

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5. Integrated Daily Longevity Strategy (PractAge Protocol)

Morning

• Bright light within 30 mins
• Hydration + electrolytes
• Delay caffeine 60–90 mins
• Exercise
• High-protein breakfast

Day

• Focused work blocks
• Walk after meals
• Time-restricted eating
• Stress regulation

Evening

• Dim lights before bed
• No screens or blockers
• Night ritual
• Magnesium, glycine if needed

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6. Monthly & Annual Monitoring

• Track blood pressure, glucose, sleep, composition
• Annual comprehensive labs
• Adjust interventions based on data

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7. PRACTAGE PHILOSOPHY

Test. Understand. Optimize. Sustain.

Longevity is not about extreme or expensive interventions. The world’s strongest evidence still points to:

• Exercise
• Nutrition
• Sleep
• Stress mastery
• Metabolic health

Technologies refine the path. Fundamentals create the foundation.

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